A different form of Immunity without IgG or IgA.

The goal of the IIPGA is to discover and model the associations between nucleotide sequence variations, primarily Single Nucleotide Polymorphisms (SNPs) and Insertion/Deletion polymorphisms (Indels), in the genes of the innate immunity pathway in humans. The Program is two-fold:

Part 1 identifies the common variable sites through sequencing and establishes their relative allele frequencies and haplotypes in four human populations having different evolutionary histories. Part two utilizes this data in case-control association studies of airways disease (i.e., asthma and chronic obstructive pulmonary disease). We have available to us a full array of bioinformatics tools for performing association analysis in human genetics.

These tools and resources are important for any association study relating innate immune responses to disease in a whole host of complex common human disorders such as: airways disease, myocardial infarction, hypertension, stroke, Crohn's Disease, allergy, and diabetes to name a few.

Two of the major goals of the IIPGA are to establish a website to disseminate data to the public and develop an educational training program that will allow individuals with varying levels of knowledge and experience to become acquainted with modern genetic techniques.

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Creating places that enhance the human experience.

Innate immunity is the body's first line of defense against pathogens, and it is present at birth. This type of immunity is non-specific, meaning it provides a general defense against a wide range of pathogens without the need for prior exposure to them. Innate immunity includes physical barriers such as the skin and mucous membranes, as well as cellular and molecular defenses such as white blood cells, inflammation, and antimicrobial proteins. It serves as a rapid response to infections and helps to prevent the spread of pathogens in the body.

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Building immunity

Processed Genes

Symbol Description Status SNPs Published

1 ADAM19 ADAM metallopeptidase domain 19 isoform 1 Completed 181 18 Jul 2003
2 BPI bactericidal/permeability-increasing protein Completed 86 17 Apr 2002
3 CARD11 caspase recruitment domain family, member 11 Completed 300 22 Apr 2004
4 CARD15 NOD2 protein Completed 52 27 Dec 2001
5 CARD4 caspase recruitment domain family, member 4 Completed 73 2 Jan 2002
6 CCL11 small inducible cytokine A11 precursor Completed 34 27 JAN 2004
7 CCL2 small inducible cytokine A2 precursor Completed 21 16 Dec 2003
8 CCL24 small inducible cytokine A24 precursor Completed 33 17 Oct 2003
9 CCL26 chemokine (C-C motif) ligand 26 precursor Completed 35 9 Oct 2003
10 CCL5 small inducible cytokine A5 precursor Completed 34 22 Apr 2004
11 CCR3 CC chemokine receptor 3 Completed 141 9 DEC 2003
12 CCR4 chemokine (C-C motif) receptor 4 Completed 12 9 DEC 2003
13 CCR5 chemokine (C-C motif) receptor 5 Completed 61 31 Dec 2003
14 CCR6 chemokine (C-C motif) receptor 6 Completed 123 9 MAR 2004
15 CD14 CD14 antigen precursor Completed 37 10 Jan 2002
16 CD209 CD209 antigen Completed 92 4 OCT 2003
17 CLCA1 calcium activated chloride channel 1 precursor Completed 203 8 Nov 2002
18 CTNNB1 catenin (cadherin-associated protein), beta 1, Completed 27 27 Mar 2002
19 DEFB1 defensin, beta 1 preproprotein Completed 142 2 Dec 2002
20 DEFB2 See Notes 0 19 Aug 2002
21 DTR Completed 64 17 Jul 2003
22 EGF epidermal growth factor (beta-urogastrone) Completed 193 9 Dec 2003
23 EGFR epidermal growth factor receptor isoform a Completed 208 9 DEC 2003
24 FOXP3 forkhead box P3 Completed 23 23 Jun 2003
25 GPR44 G protein-coupled receptor 44 Completed 61 31 Dec 2003
26 IL10 interleukin 10 precursor Completed 31 8 Jun 2001
27 IL17C interleukin 17C Completed 23 4 Oct 2003
28 IL17D interleukin 17D precursor Genotyping 80 21 May 2004
29 IL17E interleukin 17E isoform 2 Completed 38 8 Sep 2003
30 IL17F interleukin 17F precursor Completed 50 8 Sep 2003
31 IL17R interleukin 17 receptor precursor Completed 134 17 DEC 2003
32 IL18 interleukin 18 proprotein Completed 86 19 Nov 2002
33 IL18BP interleukin 18 binding protein precursor Completed 37 18 Sep 2002
34 IL18R1 interleukin 18 receptor 1 precursor Completed 151 14 Jan 2003
35 IL18RAP interleukin 18 receptor accessory protein Completed 124 29 Jan 2003
36 IL23A interleukin 23, alpha subunit p19 precursor Completed 6 8 SEP 2003
37 IL23R interleukin 23 receptor precursor Completed 102 4 OCT 2003
38 IRAK1 interleukin-1 receptor-associated kinase 1 Completed 28 4 Aug 2003
39 IRAK2 interleukin-1 receptor-associated kinase 2 Completed 135 18 Jul 2003
40 IRAK3 interleukin-1 receptor-associated kinase 3 Completed 71 21 Jul 2003
41 ITGAM integrin alpha M precursor Completed 105 4 FEB 2004
42 LBP lipopolysaccharide-binding protein precursor Completed 77 24 Apr 2002
43 LTBR lymphotoxin beta receptor Completed 53 16 Jan 2004
44 LY64 Completed 88 13 Jun 2002
45 LY86 MD-1, RP105-associated Completed 32 22 May 2002
46 LY96 MD-2 protein Completed 15 17 Apr 2002
47 MEFV Mediterranean fever protein Completed 79 17 Jul 2003
48 MUC2 mucin 2 Genotyping 257 10 Jun 2004
49 MUC7 mucin 7, salivary Completed 138 22 Apr 2004
50 MYD88 myeloid differentiation primary response gene Completed 8 28 Mar 2002
51 NGFB nerve growth factor, beta polypeptide precursor Completed 83 23 Jun 2003
52 NGFR nerve growth factor receptor precursor Completed 83 8 Oct 2003
53 NOS1 nitric oxide synthase 1 (neuronal) Completed 215 22 Apr 2004
54 NTRK1 neurotrophic tyrosine kinase, receptor, type 1 Genotyping 99 16 Dec 2003
55 PDCD1 programmed cell death 1 precursor Completed 69 23 Jun 2003
56 PTGDR prostaglandin D2 receptor Genotyping 79 4 FEB 2004
57 SCGB1A1 secretoglobin, family 1A, member 1 Completed 45 9 Dec 2003
58 SOCS2 suppressor of cytokine signaling-2 Completed 42 22 Apr 2004
59 SOCS3 suppressor of cytokine signaling 3 Completed 18 22 Apr 2004
60 SOCS4 suppressor of cytokine signaling 4 Genotyping 125 6 May 2004
61 SOCS5 suppressor of cytokine signaling 5 Genotyping 114 6 May 2004
62 STAT1 signal transducer and activator of transcription Completed 136 9 Dec 2003
63 TGFA transforming growth factor, alpha Completed 160 18 Jul 2003
64 TGFB1 transforming growth factor, beta 1 Completed 66 21 Jul 2003
65 TGFB2 transforming growth factor, beta 2 Completed 82 1 Jun 2003
66 TGFB3 transforming growth factor, beta 3 Completed 107 1 Jun 2003
67 TGFBR1 transforming growth factor, beta receptor I Completed 58 21 Jul 2003
68 TGFBR2 TGF-beta type II receptor isoform B precursor Completed 99 9 Jul 2003
69 TGFBR3 transforming growth factor, beta receptor III Completed 121 17 Jun 2003
70 TLR1 toll-like receptor 1 Completed 77 18 Sep 2002
71 TLR10 toll-like receptor 10 precursor Completed 76 7 Apr 2003
72 TLR2 toll-like receptor 2 Completed 28 10 Sep 2002
73 TLR3 toll-like receptor 3 Completed 23 29 Apr 2002
74 TLR4 toll-like receptor 4 precursor Completed 44 13 Jun 2001
75 TLR5 toll-like receptor 5 Completed 143 27 Dec 2002
76 TLR6 toll-like receptor 6 Completed 53 15 Oct 2001
77 TLR7 toll-like receptor 7 Completed 99 27 Aug 2002
78 TLR8 toll-like receptor 8 isoform 2 Completed 72 18 Sep 2002
79 TLR9 toll-like receptor 9 isoform A precursor Completed 22 20 Sep 2001
80 TNFRSF18 tumor necrosis factor receptor superfamily, Completed 42 4 Aug 2003
81 TOLLIP toll interacting protein Completed 199 18 Sep 2002
82 TRIF Completed 36 21 Jul 2003
83 TSLP thymic stromal lymphopoietin isoform 2 Completed 38 4 Aug 2003

Above is the current list of genes at some stage of completion by the InnateImmunity project. Click on the name of a gene to see SNP and genotype data for that gene. Click on a column header to sort by that property.

Reports and Documentation

Report Generator using default pipeline parameters

Report Generator for user-supplied data sets

Summary Statistics

Sequencing Methods

Data Release Policy

Epidemiological Methods

Genotyping Methods

Statistical Methods

Bioinformatics Methods

All Genes

Biological Significance of Innate Immunity genes

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ITGB2 integrin, beta 2 precursor

MUC5AC

NOS2A nitric oxide synthase 2A isoform 2

CCL3 chemokine (C-C motif) ligand 3

CCL4 chemokine C-C motif ligand 4 isoform 1

LMAN1 lectin, mannose-binding, 1 precursor

IL8RA interleukin 8 receptor alpha

IL8RB interleukin 8 receptor beta

SOCS6 suppressor of cytokine signaling 6