Genes and Anti-Cancer Agents

Elevated levels of J02923 (lymphocyte cytosolic protein-1, LCP1, L-plastin, pp65) is associated with increased sensitivity to 624044
Agent 624044 is 4-Thiazolidinecarboxylic acid, 3-[[6-[2-oxo-2-(phenylthio)ethyl]-3-cyclohexen-1-yl]acetyl]-2 thioxo-, methyl ester, [1R-[1a(R*),6a]]- (9CI))
LCP1 is an actin-binding protein involved in leukocyte adhesion
A role for LCP1 in tumorogenicity has been previously postulated
Low level expression of LCP1 is thought to occur in most human cancer cell lines
Other thiazolidine carboxylic acid derivatives are known to inhibit tumor cell growth

Elevated levels of J02923 (lymphocyte cytosolic protein-1, LCP1, L-plastin, pp65) is associated with increased sensitivity to 624044