| Information |
|---|
| MD-2 protein |
| InnateImmunity |
|
chr8 (+) (chr8:75066144-75103859) |
|
NM_015364
|
| 15 |
| 0 |
| 2 |
| 0 |
|
[ SNPper ]
[ GoldenPath ]
[ Gene Image ]
[ LocusLink ]
[ Omim ]
[ PubMed ]
|
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Note that LY96 used to be called MD-2.
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In mammals, LPS initiates its biological activities through a heteromeric receptor complex containing CD14, TLR4, and at least one other protein, MD-2. LPS binds directly to CD14 and is cross-linked specifically to TLR4 and MD-2 only when co-expressed with CD14. Thus LPS is in close proximity to the three known proteins of its membrane receptor complex, and binds directly to each of the members of the tripartite LPS receptor complex. MD-2 is a required component of the LPS signaling complex and (similar to CD14) can function as a soluble receptor for cells that do not otherwise express it. Molecular genetic analysis of an LPS-nonresponder mutant cell line has recently shown that a point mutation in a conserved region of MD-2 abolishes LPS-induced signaling. Of note, decreased expression of MD-2 and TLR4 correlates with protection of intestinal epithelial cells against dysregulated expression of proinflammatory genes in response to bacterial LPS..
( See Omim for more ... ) |
