caspase recruitment domain family, member 4

Search:

User: Anonymous User ( Login | Register )

The following information is based on the unmasked version of the consensus sequence. We have also generated data for the masked version of the assembly. There is also an Introduction available if you are looking for a place to get started.

Information
Name	caspase recruitment domain family, member 4
Source	InnateImmunity
Chromosome	chr7 (-) (chr7:30430675-30484790)
Accession	NM_006092
SNPs	73
Indels	0
Populations	4
Subjects	0
Links	[ SNPper ] [ GoldenPath ] [ Gene Image ] [ LocusLink ] [ Omim ] [ PubMed ]
Biological Significance	CARD4 (aka NOD1) is a member of a growing family of intracellular proteins with structural homology to apoptosis regulators Apaf-1/Ced-4 and a class of plant disease-resistant gene products. Bacterial LPS, but not other pathogen components tested, has been found to induced TLR4- and MyD88-independent NF-kB activation in human embryonic kidney 293T cells expressing trace amounts of Nod1. Nod2, another Nod family member, also conferred responsiveness to bacterial components but with a response pattern different from that observed with Nod1. The leucine-rich repeats of Nod1 and Nod2 were required for LPS-induced NF-kB activation. An LPS-binding activity could be specifically coimmunopurified with Nod1 from cytosolic extracts. These observations suggest that Nod1 and Nod2 are mammalian gene products that may function as cytosolic receptors for pathogen components derived from invading bacteria. ( See Omim for more ... )