| Information |
|---|
| toll-like receptor 4 precursor |
| InnateImmunity |
|
chr9 (+) (chr9:119506431-119519585) |
|
NM_138554
|
| 44 |
| 0 |
| 2 |
| 0 |
|
[ SNPper ]
[ GoldenPath ]
[ Gene Image ]
[ LocusLink ]
[ Omim ]
[ PubMed ]
|
|
TLR4 is a critical component of the heteromeric receptor complex that transduces signals delivered by lipopolysaccharide (LPS) of Gram-negative bacteria. CD14, a molecule selectively expressed by monocytes and granulocytes, an d MD-2 are also involved in LPS-mediated signaling. C3H/HeJ mice which bear mutations in the Tlr4 gene exhibit defective LPS signaling, and TLR4 knockout mice are selectively impaired in their ability to recognize Gram-negative bacteria. In humans, TLR4 mutations have been found to be associated with endotoxin hyporesponsiveness. Recognition of viral products has also been proposed to be mediated by TLR4, and studies in animal models point to a major role of TLR4 in the response to respiratory sync ytial virus infection.
( See Omim for more ... ) |
