Table of contents

An Overview of Genetic Epidemiology

Course Outline

Slide 3

Slide 4

Slide 5

Overview of Complex Trait Genetics

Candidate Gene vs Genome Screen

Broad Genetic Epidemiology Study Design Categories

Association Studies

A Comprehensive Review of Genetic Association Studies Hirschhorn JN, Lohmueller KE, Byrne E, Hirschhorn K. Genetic Med 2002; 4:45-61

Slide 11

Meta-Analysis of Genetic Association Studies Supports a Contribution of Common Variants to Susceptibility to Common Disease Lohmueller KE, Pearce CL, Pike M, Lander ES, Hirschhorn JN. Nature Gen 2003; 177:182

Issues in Case Control Association Studies

Evaluation of Candidate Gene Case-Control Association Studies

Slide 15

Slide 16

Slide 17

Methods for Assessing Population Stratification

Methods for Controlling for Population Stratification if Detected

www.innateimmunity.net

Analysis Pipeline

Slide 22

General SNP Information

SNP Discovery Data

Slide 25

Association Data

Slide 27

PGA Tools

The End

Author: Scott T. Weiss, M.D., M.S.

Homepage: https://innateimmunity.net/

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