Table of contents

Phenotypes for Complex Trait Genetics

Objectives

Phenotype

A disease example: Asthma

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Different Phenotypic Characteristics

Closely related characteristics

Problem

Possible Solution

Asthma in an Algorithm

Currently Known Risk Factors

Asthma severity risk factors

Inflammation?

Slide 14

Cardiac Disease Example

QTLs

Linkage studies for LVH in normotensive animals

Slide 18

Mammalial Phenotype Browser

From Mice and Rats to Humans

Beware of Ascertainment Bias

Summary

Slide 23

Author: Adrienne G. Randolph, MD, MSc

Homepage: https://innateimmunity.net/

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