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Table of contents

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Slide 2

B2AR and Asthma Genetics

Slide 4

Why Use CAMP Trios Instead of Cases/Controls?

Slide 6

Drysdale (2000) B2AR SNPs/Haplotypes

SNPs Included in 2-AR Haplotyping

Drysdale SNPs in B2AR Analyzed with BEST Program

B2AR SNPs

Slide 11

Slide 12

Slide 13

Slide 14

CAMP B2AR Association Analysis: Analytical Approach

Slide 16

TRANSMIT Single SNP Analysis in CAMP: Issues

Slide 18

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Slide 20

Comparison of Common B2AR Haplotypes in CAMP and Drysdale et al.

Family-Based Association Analysis of B2AR Haplotypes in CAMP

Haplotype Imputation Using PHASE: PrettyBase Files

Haplotype Imputation Using PHASE: PHASE Output in CAMP Parents

Slide 25

Family-Based Association Analysis of B2AR Haplotypes in CAMP: Issues

Slide 27

Multiple Comparisons in CAMP B2AR Association Analysis

Slide 29

DEFB1: Variation Discovery

Slide 31

DEFB1: SNP Genotyping

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Slide 35

DEFB1 and Asthma: Discussion

Considerations in Case-Control vs. TDT Association Analysis

Slide 38

Author: Edwin K. Silverman, M.D., Ph.D.

E-mail: reeks@channing.harvard.edu

Homepage: http://innateimmunity.net/

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