Table of contents

Genetics of Human Complex Diseases

Overview:

Motivation for family-based study designs

Motivation (cont.)

Slide 5

Slide 6

Case-Control Studies:

Possible Solutions:

Stratification: Box-plots: trait by genotype (CAMP)

The Transmission-Disequilibrium Test (TDT) by Spielman

The Transmission-Disequilibrium Test (TDT)

Slide 12

Slide 13

Slide 14

Advantages of the TDT

Extensions of the TDT

The FBAT concept

The FBAT test statistic (Laird et al (2000)):

Advantages of FBAT

Coding of the phenotype

Power considerations

Slide 22

Slide 23

Slide 24

Other advantages of FBATs

Testing strategies for FBATs

Software

Author: Christoph Lange

Homepage: https://innateimmunity.net/

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